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Other ALDH2 approaches: Many investigational drugs showed promise in pre-clinical studies, including selective and reversible ALDH2 inhibitors (e.g., ANS-6637) and genetic targeting of liver ALDH2 messenger RNA to locally reduce hepatic ALDH2 expression (305, 306)

An increased intestinal PEG-400 permeability in first-degree healthy relatives of Crohn's disease patients was described for the first time in 1986 (107), whereas three other studies could not reproduce these findings by using the same probe (108110)

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Patients with both PSC and UC have a 45 times higher risk of developing colorectal dysplasia or cancer than those with UC alone

This highlights an important distinction between biological plausibility and clinical evidence

2026;49:413-423 - routine-care cohort, semaglutide arm n=1,393, -8.8% at 6 months