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Consequently, researchers have devoted decades to studying incretins, postulating that incretin-based therapies could potentially reverse this diminished incretin effect and restore insulin secretion in patients with T2DM
Peripheral application of fluorescently labeled liraglutide binds GLP-1R within the ARC (Secher et al., 2014)

Inability to keep fluids down for 24 hours

He pointed to retention as the real issue GLP-1s are weekly injections, and stopping means the weight comes back

2,13 In more severe cases, complications such as gastroparesis, pancreatitis, and GI bleeding may occur