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E., Juliano, L
Leading players include Novo Nordisk, Eli Lilly, Merck & Co., Sanofi, AstraZeneca, Takeda Pharmaceutical Company Limited, Boehringer Ingelheim, Novartis, Johnson & Johnson, Bayer, Pfizer, and Janssen Pharmaceuticals
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The clinically most relevant and important action of DPP-4 inhibitors is the endogenous elevation of the incretin hormone concentration of GLP-1 that consecutively leads to a glucose-dependent stimulation of insulin secretion and an inhibition of glucagon secretion (10)
Some patients who tolerate once-weekly injectable GLP-1s may find daily oral GI exposure more difficult, or vice versa
