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We analyzed the ChIP-seq data reported recently 26 and identified a super-enhancer encompassing the mouse Cyp8b1 (Supplementary Fig

In pre-clinical models, we and others have shown that enhancing ER actions in -cells protects survival and function in the face of multiple diabetic insults 2,3,4,5,6,7,8,9,10

Another large study showed that using GLP-1s may help prevent immune-related diseases in people with diabetes or obesity People with diabetes who took GLP-1 drugs had a lower chance of developing rheumatoid arthritis, gout, and osteoarthritis compared to people on other diabetes medications

27 and Supplementary Figs

Oxidative stress refers to a state of imbalance between oxidation and antioxidant effects in the body, favoring oxidation, leading to inflammatory infiltration of neutrophils, increased protease secretion, and production of a large number of oxidative intermediates

#MASH #Hepatology #MetabolicHealth #GLP1 To view or add a comment, sign in Narrative review proposes pancreatic exocrine fibrosis and profibrotic signalling as key drivers of type 3c diabetes, with a potential role in type 2 and type 1 diabetes, and summarises unanswered questions & suggests potential novel therapeutic targets To view or add a comment, sign in We are very grateful to Diabetologia for inviting us to review the growing evidence supporting a profibrotic signalling cycle involving stellate cells, macrophages and islet endocrine cells themselves in the pathogenesis of pancreatogenic diabetes including diabetes associated with pancreatic cancer