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The powder is reconstituted with the diluent before administration, yielding a yellow solution stabilized by excipients such as mannitol, polysorbate 80, sodium phosphate, and trehalose dihydrate

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Preclinical signals regarding potential effects on thyroid C-cells (observed with GLP-1 agonists as a class), as well as theoretical questions about bone metabolism and cardiovascular function, are being monitored in ongoing trials

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