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In biological systems, the nucleophile may be macromolecules, such as nucleic acids (Mller et al., 1998) and proteins (Eyre et al., 1995)
Durairaj C

Chem Res Toxicol 21:145159 Anders MW, Lash L, Dekant W, Elfarra AA, Dohn DR (1988) Biosynthesis and biotransformation of glutathione S -conjugates to toxic metabolites

70 Other studies have shown that NAC reacts strongly with the endogenous aldehydes, such as 4-HNE generated during human lipid peroxidation
Kaur R., Naaz F., Sharma S., et al., Screening of a Library of 4Aryl/Heteroaryl4HFused Pyrans for Xanthine Oxidase Inhibition: Synthesis, Biological Evaluation and Docking Studies, Medicinal Chemistry Research 24 (2015): 33343349, 10.1007/s00044-015-1382-0

It also measures the greatest distance between two similar lesions in each anatomical region, such as axillae, buttocks, genitalia, and others, on both the left and right sides of the body (216)
